| UFC Fight Night: Sandhagen vs. Figueiredo | Daniel Rodriguez | 1079 →1103(+24) | Santiago Ponzinibbio | 1094 →1070(-24) | Welterweight | Loss | KO |
| UFC Fight Night: Dern vs. Ribas 2 | Santiago Ponzinibbio | 1073 →1094(+21) | Carlston Harris | 1044 →1023(-21) | Welterweight | Win | KO |
| UFC Fight Night: Namajunas vs. Cortez | Muslim Salikhov | 1052 →1074(+22) | Santiago Ponzinibbio | 1096 →1073(-23) | Welterweight | Loss | S-DEC |
| UFC 287: Pereira vs. Adesanya 2 | Kevin Holland | 1077 →1103(+26) | Santiago Ponzinibbio | 1122 →1096(-26) | Welterweight | Loss | KO |
| UFC 282: Blachowicz vs. Ankalaev | Santiago Ponzinibbio | 1097 →1122(+25) | Alex Morono | 1120 →1095(-25) | Catch Weight | Win | KO |
| UFC Fight Night: Holm vs. Vieira | Michel Pereira | 1068 →1091(+23) | Santiago Ponzinibbio | 1120 →1097(-23) | Welterweight | Loss | S-DEC |
| UFC 269: Oliveira vs. Poirier | Geoff Neal | 1071 →1095(+24) | Santiago Ponzinibbio | 1144 →1120(-24) | Welterweight | Loss | S-DEC |
| UFC Fight Night: Rozenstruik vs. Sakai | Santiago Ponzinibbio | 1128 →1144(+16) | Miguel Baeza | 1070 →1053(-17) | Welterweight | Win | U-DEC |
| UFC Fight Night: Holloway vs. Kattar | Li Jingliang | 1094 →1121(+27) | Santiago Ponzinibbio | 1155 →1128(-27) | Welterweight | Loss | KO |
| UFC Fight Night: Magny vs. Ponzinibbio | Santiago Ponzinibbio | 1130 →1155(+25) | Neil Magny | 1152 →1127(-25) | Welterweight | Win | KO |
| UFC Fight Night: Lawler vs. Dos Anjos | Santiago Ponzinibbio | 1112 →1130(+18) | Mike Perry | 1072 →1055(-17) | Welterweight | Win | U-DEC |
| UFC Fight Night: Nelson vs. Ponzinibbio | Santiago Ponzinibbio | 1088 →1112(+24) | Gunnar Nelson | 1113 →1088(-25) | Welterweight | Win | KO |
| UFC Fight Night: Lewis vs. Browne | Santiago Ponzinibbio | 1068 →1088(+20) | Nordine Taleb | 1058 →1039(-19) | Welterweight | Win | U-DEC |
| UFC Fight Night: Rodriguez vs. Caceres | Santiago Ponzinibbio | 1048 →1068(+20) | Zak Cummings | 1061 →1040(-21) | Welterweight | Win | U-DEC |
| UFC on FOX: Teixeira vs Evans | Santiago Ponzinibbio | 1023 →1048(+25) | Court McGee | 1050 →1025(-25) | Welterweight | Win | KO |
| UFC Fight Night: Namajunas vs. VanZant | Santiago Ponzinibbio | 1001 →1023(+22) | Andreas Stahl | 980 →958(-22) | Welterweight | Win | KO |
| UFC Fight Night: Machida vs Romero | Lorenz Larkin | 982 →1008(+26) | Santiago Ponzinibbio | 1027 →1001(-26) | Welterweight | Loss | KO |
| UFC Fight Night: Bigfoot vs Mir | Santiago Ponzinibbio | 1005 →1027(+22) | Sean Strickland | 1045 →1023(-22) | Welterweight | Win | U-DEC |
| UFC Fight Night: Bigfoot vs Arlovski | Santiago Ponzinibbio | 981 →1005(+24) | Wendell Oliveira Marques | 1000 →975(-25) | Welterweight | Win | KO |
| UFC Fight Night: Belfort vs Henderson 2 | Ryan LaFlare | 1021 →1040(+19) | Santiago Ponzinibbio | 1000 →981(-19) | Welterweight | Loss | U-DEC |
